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植物性的解决方案使血友病治疗更有效

发布时间:2018-09-17 11:34 作者:admin 来源: 点击: 字号:

hemophilia

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Patients with hemophilia are often forced to live in a bubble。 Even the smallest cut can cause significant blood loss, and often times these minor accidents can also cause internal bleeding that affects organs and threatens life。 Some treatments have proven effective at keeping hemophilia at bay, at least to a degree, yet some groups of patients do not respond well because their immune system attacks the treatment。 Scientists at University of Florida Health and the University of Pennsylvania may have provided a viable solution to this group after they engineered plants that twat the immune response to tolerate rather than attack the clotting factors。

Plants that stop bleeding

Hemophilia is a rare, inheritable bleeding disorder in which the blood doesn’;t clot normally。 People born with hemophilia have little or no clotting factor。 Clotting factor is a protein needed for normal blood clotting。 There are several types of clotting factors。 These proteins work with platelets –; small blood cell fragments that form in the bone marrow –; to help the blood clot。

Hemophilia A, the most common form,  occurs when babies are born with a defective gene on the X chromosome。 Because girls have two X chromosomes — giving them two shots at having a working version of the gene — the disease typically only affects boys。 Worldwide, one in 7,500 male babies is born with this disease。

To treat hemophilia, doctors prescribe a treatment where certain proteins are injected to stem the flow from a wound。 After receiving factor VIII treatments (the clotting proteins), some 20 to 30 percent of patients, however, develop antibodies which attack the proteins instead of letting them do their job。 These antibodies are known as inhibitors。

“The only current treatments against (antibody) formation cost $1 million and are risky for patients,” said Henry Daniell, Ph。D。, interim chairman of biochemistry at the University of Pennsylvania School of Dental Medicine and a co-author on the study。 “Our technique, which uses plant-based capsules, has the potential to be a cost-effective and safe alternative。”

Daniell and colleagues engineered tobacco plants that were modified to express factor VIII DNA and another substance that can safely cross the intestinal walls and enter the bloodstream。 These resulting veggies were fed to hemophiliac mice twice each week for two months and compared them with mice that were fed unmodified plant material。 They then gave the mice infusions of factor VIII, just as human hemophilia patients would receive。 A****pected, the control group formed high levels of inhibitors。 In contrast, the mice fed the experimental plant material formed fewer inhibitors — on average, seven times fewer。

本文源自: 环亚娱乐

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