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胎儿从母体血液DNA测序

发布时间:2018-09-13 15:13 作者:admin 来源: 点击: 字号:

Huge leaps in research within the field of genetics have enabled fetal DNA sequencing from maternal blood。 This has made it possible to determine whether the unborn baby is suffering from any autoimmune conditions or chromosomal abnormalities such as Down’s syndrome, Turner’s syndrome or Neural tube defects such as Spina Bifida。

Up until the recent present, fetal DNA samples could only be collected using invasive sampling methods such as transcervical or transabdominal chorionic villus sampling or amniocentesis。 In order to collect fetal DNA, biopsies of the chorionic villi lining the placental wall are required。 With amniocentesis, sampling of around 20ML of amniotic fluid is required。 Both these tests carry certain risks, the worst being the risk of miscarriage。 Statistics claim that these prenatal testing sampling methods have a miscarriage rate of 1%。 However, it is not uncommon for women to miscarry naturally in their second trimester, the period of pregnancy in which these tests are carried out, and thus, it is hard to know whether any resulting miscarriage was in fact, due to the invasive procedure or to natural circumstances。

The Placenta

Along with the umbilical cord and the amniotic sac, this organ is vital to the survival of the fetus。 The
placenta is a thin lining which separates the fetus from the mother。 Elimination of byproducts and exchange of oxygen also takes place via this important organ。 Importantly, blood supply to the baby is mediated by the placental wall。 Fetal blood reaches the placental wall and uptakes the required oxygen。 On the other hand, simultaneous to this process, waste products from the fetus are transferred into the maternal blood。 The placenta however, keeps the fetal blood and the maternal blood functionally separate。 Despite this, fetal DNA finds in either its nucleated form or as cell-free DNA still finds its way into the maternal blood。

本文源自: 环亚娱乐

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